InforLorV4, Main, Exploration, bibRecord, 000782

Geographic differences in heart failure trials

Identifieur interne : 000782 ( Main/Exploration ); précédent : 000781; suivant : 000783

Geographic differences in heart failure trials

Auteurs : João Pedro Ferreira [France, Portugal] ; Nicolas Girerd [France] ; Patrick Rossignol [France] ; Faiez Zannad [France]

Source :

European Journal of Heart Failure [ 1388-9842 ] ; 2015-09.

RBID : ISTEX:E81A056EF875DD82957E2481123EB3FF1537D2B6

Abstract

Randomized controlled trials (RCTs) are essential to develop advances in heart failure (HF). The need for increasing numbers of patients (without substantial cost increase) and generalization of results led to the disappearance of international boundaries in large RCTs. The significant geographic differences in patients' characteristics, outcomes, and, most importantly, treatment effect observed in HF trials have recently been highlighted. Whether the observed regional discrepancies in HF trials are due to trial‐specific issues, patient heterogeneity, structural differences in countries, or a complex interaction between factors are the questions we propose to debate in this review. To do so, we will analyse and review data from HF trials conducted in different world regions, from heart failure with preserved ejection fraction (HF‐PEF), heart failure with reduced ejection fraction (HF‐REF), and acute heart failure (AHF). Finally, we will suggest objective and actionable measures in order to mitigate regional discrepancies in future trials, particularly in HF‐PEF where prognostic modifying treatments are urgently needed and in which trials are more prone to selection bias, due to a larger patient heterogeneity.

Url:

https://api.istex.fr/ark:/67375/WNG-X5SQ1JBG-K/fulltext.pdf

DOI: 10.1002/ejhf.326

Affiliations:

Le document en format XML

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Geographic differences in heart failure trials

Geographic differences in heart failure trials

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